| Holyoke to Orangevale (California) | 2,531.21 mi (4,073.59 km) |
| Holyoke to Orchards (Washington) | 2,452.88 mi (3,947.53 km) |
| Holyoke to Orcutt (California) | 2,596.82 mi (4,179.18 km) |
| Holyoke to Oregon (Ohio) | 555.64 mi (894.22 km) |
| Holyoke to Oregon (Wisconsin) | 852.23 mi (1,371.54 km) |
| Holyoke to Oregon City (Oregon) | 2,461.18 mi (3,960.89 km) |
| Holyoke to Orem (Utah) | 2,015.34 mi (3,243.37 km) |
| Holyoke to Orinda (California) | 2,600.31 mi (4,184.80 km) |
| Holyoke to Orland Park (Illinois) | 782.71 mi (1,259.65 km) |
| Holyoke to Orlando (Florida) | 1,066.66 mi (1,716.62 km) |
| Holyoke to Ormond Beach (Florida) | 1,009.25 mi (1,624.24 km) |
| Holyoke to Oro Valley (Arizona) | 2,191.62 mi (3,527.06 km) |
| Holyoke to Oroville (California) | 2,528.28 mi (4,068.87 km) |
| Holyoke to Oshkosh (Wisconsin) | 811.33 mi (1,305.71 km) |
| Holyoke to Oskaloosa (Iowa) | 1,030.47 mi (1,658.38 km) |
