| Holyoke to Olympia Heights (Florida) | 1,220.31 mi (1,963.91 km) |
| Holyoke to Omaha (Nebraska) | 1,205.04 mi (1,939.33 km) |
| Holyoke to On Top of the World Designated Place (Florida) | 1,053.46 mi (1,695.39 km) |
| Holyoke to Onalaska (Wisconsin) | 942.52 mi (1,516.84 km) |
| Holyoke to Oneida (New York) | 164.74 mi (265.12 km) |
| Holyoke to Oneonta (New York) | 125.01 mi (201.18 km) |
| Holyoke to Ontario (California) | 2,478.42 mi (3,988.63 km) |
| Holyoke to Ontario (Oregon) | 2,212.36 mi (3,560.45 km) |
| Holyoke to Opa-locka (Florida) | 1,207.14 mi (1,942.70 km) |
| Holyoke to Opelika (Alabama) | 959.08 mi (1,543.49 km) |
| Holyoke to Opelousas (Louisiana) | 1,344.33 mi (2,163.49 km) |
| Holyoke to Orange (California) | 2,496.79 mi (4,018.19 km) |
| Holyoke to Orange (Texas) | 1,437.55 mi (2,313.51 km) |
| Holyoke to Orange City (Florida) | 1,036.79 mi (1,668.55 km) |
| Holyoke to Orangeburg (South Carolina) | 750.43 mi (1,207.70 km) |
