| Holyoke to Odessa (Texas) | 1,775.11 mi (2,856.76 km) |
| Holyoke to Ogden (Utah) | 2,011.17 mi (3,236.66 km) |
| Holyoke to Oildale (California) | 2,509.20 mi (4,038.16 km) |
| Holyoke to Ojus (Florida) | 1,201.53 mi (1,933.68 km) |
| Holyoke to Okemos (Michigan) | 600.57 mi (966.52 km) |
| Holyoke to Oklahoma City (Oklahoma) | 1,411.26 mi (2,271.20 km) |
| Holyoke to Okmulgee (Oklahoma) | 1,331.17 mi (2,142.31 km) |
| Holyoke to Olathe (Kansas) | 1,183.37 mi (1,904.46 km) |
| Holyoke to Old Jamestown (Missouri) | 953.56 mi (1,534.60 km) |
| Holyoke to Oldsmar (Florida) | 1,128.82 mi (1,816.66 km) |
| Holyoke to Olean (New York) | 296.74 mi (477.55 km) |
| Holyoke to Olive Branch (Mississippi) | 1,052.92 mi (1,694.51 km) |
| Holyoke to Olivehurst (California) | 2,538.24 mi (4,084.91 km) |
| Holyoke to Olney (Maryland) | 314.19 mi (505.64 km) |
| Holyoke to Olympia (Washington) | 2,450.66 mi (3,943.96 km) |
