| Holyoke to Chicago (Illinois) | 771.66 mi (1,241.87 km) |
| Holyoke to Atlanta (Georgia) | 865.88 mi (1,393.50 km) |
| Holyoke to St. Louis (Missouri) | 956.40 mi (1,539.18 km) |
| Holyoke to Minneapolis (Minnesota) | 1,046.64 mi (1,684.40 km) |
| Holyoke to Tampa (Florida) | 1,126.04 mi (1,812.19 km) |
| Holyoke to Miami (Florida) | 1,213.79 mi (1,953.41 km) |
| Holyoke to Boston (Massachusetts) | 79.89 mi (128.57 km) |
| Holyoke to Queens (New York) | 117.46 mi (189.03 km) |
| Holyoke to New York (New York) | 124.19 mi (199.86 km) |
| Holyoke to Dallas (Texas) | 1,466.86 mi (2,360.69 km) |
| Holyoke to Houston (Texas) | 1,526.48 mi (2,456.63 km) |
| Holyoke to Denver (Colorado) | 1,679.65 mi (2,703.14 km) |
| Holyoke to Brooklyn (New York) | 127.46 mi (205.13 km) |
| Holyoke to Phoenix (Arizona) | 2,210.79 mi (3,557.93 km) |
| Holyoke to Las Vegas (Nevada) | 2,294.18 mi (3,692.12 km) |
| Holyoke to Seattle (Washington) | 2,417.06 mi (3,889.88 km) |
| Holyoke to Portland (Oregon) | 2,460.84 mi (3,960.34 km) |
| Holyoke to Riverside (California) | 2,470.75 mi (3,976.29 km) |
| Holyoke to Philadelphia (Pennsylvania) | 200.10 mi (322.03 km) |
| Holyoke to San Diego (California) | 2,492.12 mi (4,010.67 km) |
| Holyoke to Los Angeles (California) | 2,517.02 mi (4,050.75 km) |
| Holyoke to San Francisco (California) | 2,617.04 mi (4,211.71 km) |
| Holyoke to Baltimore (Maryland) | 289.06 mi (465.20 km) |
| Holyoke to Washington (District of Columbia) | 323.92 mi (521.30 km) |
| Holyoke to Detroit (Michigan) | 534.42 mi (860.07 km) |
