| Holyhead to Medford (New York) | 3,198.45 mi (5,147.42 km) |
| Holyhead to Medford (Oregon) | 4,882.02 mi (7,856.85 km) |
| Holyhead to Medina (Ohio) | 3,535.94 mi (5,690.55 km) |
| Holyhead to Medulla (Florida) | 4,184.48 mi (6,734.27 km) |
| Holyhead to Mehlville (Missouri) | 3,986.45 mi (6,415.57 km) |
| Holyhead to Melbourne (Florida) | 4,122.56 mi (6,634.62 km) |
| Holyhead to Melissa (Texas) | 4,487.89 mi (7,222.55 km) |
| Holyhead to Melrose (Massachusetts) | 3,050.11 mi (4,908.68 km) |
| Holyhead to Melrose Park (Illinois) | 3,730.16 mi (6,003.11 km) |
| Holyhead to Melville (New York) | 3,217.19 mi (5,177.56 km) |
| Holyhead to Melvindale (Michigan) | 3,534.27 mi (5,687.85 km) |
| Holyhead to Memphis (Florida) | 4,229.19 mi (6,806.23 km) |
| Holyhead to Memphis (Tennessee) | 4,141.27 mi (6,664.73 km) |
| Holyhead to Menasha (Wisconsin) | 3,643.86 mi (5,864.23 km) |
| Holyhead to Mendota (California) | 5,128.26 mi (8,253.14 km) |
