| Holyhead to Euless (Texas) | 4,530.60 mi (7,291.30 km) |
| Holyhead to Eureka (California) | 5,008.07 mi (8,059.72 km) |
| Holyhead to Eureka (Missouri) | 3,999.25 mi (6,436.17 km) |
| Holyhead to Eustis (Florida) | 4,125.82 mi (6,639.87 km) |
| Holyhead to Evans (Colorado) | 4,417.16 mi (7,108.73 km) |
| Holyhead to Evans (Georgia) | 3,907.99 mi (6,289.30 km) |
| Holyhead to Evanston (Illinois) | 3,717.05 mi (5,982.01 km) |
| Holyhead to Evanston (Wyoming) | 4,578.43 mi (7,368.27 km) |
| Holyhead to Evansville (Indiana) | 3,904.68 mi (6,283.98 km) |
| Holyhead to Everett (Massachusetts) | 3,052.03 mi (4,911.77 km) |
| Holyhead to Everett (Washington) | 4,543.96 mi (7,312.80 km) |
| Holyhead to Evergreen Park (Illinois) | 3,732.57 mi (6,006.99 km) |
| Holyhead to Ewa Beach (Hawaii) | 7,040.08 mi (11,329.91 km) |
| Holyhead to Ewa Gentry (Hawaii) | 7,039.33 mi (11,328.70 km) |
| Holyhead to Excelsior Springs (Missouri) | 4,092.91 mi (6,586.91 km) |
