| Holyhead to Enumclaw (Washington) | 4,581.41 mi (7,373.07 km) |
| Holyhead to Ephrata (Pennsylvania) | 3,355.07 mi (5,399.46 km) |
| Holyhead to Erie (Colorado) | 4,444.57 mi (7,152.84 km) |
| Holyhead to Erie (Pennsylvania) | 3,421.48 mi (5,506.34 km) |
| Holyhead to Erlanger (Kentucky) | 3,741.02 mi (6,020.59 km) |
| Holyhead to Escanaba (Michigan) | 3,524.93 mi (5,672.82 km) |
| Holyhead to Escondido (California) | 5,229.01 mi (8,415.28 km) |
| Holyhead to Española (New Mexico) | 4,694.35 mi (7,554.82 km) |
| Holyhead to Essex (Maryland) | 3,405.61 mi (5,480.80 km) |
| Holyhead to Essex Junction (Vermont) | 3,046.10 mi (4,902.22 km) |
| Holyhead to Estelle (Louisiana) | 4,414.83 mi (7,104.98 km) |
| Holyhead to Estero (Florida) | 4,255.48 mi (6,848.54 km) |
| Holyhead to Euclid (Ohio) | 3,501.53 mi (5,635.17 km) |
| Holyhead to Eufaula (Alabama) | 4,111.60 mi (6,616.98 km) |
| Holyhead to Eugene (Oregon) | 4,791.00 mi (7,710.37 km) |
