| Holyhead to Emeryville (California) | 5,124.43 mi (8,246.97 km) |
| Holyhead to Emmaus (Pennsylvania) | 3,311.84 mi (5,329.89 km) |
| Holyhead to Emporia (Kansas) | 4,212.19 mi (6,778.87 km) |
| Holyhead to Encinitas (California) | 5,240.10 mi (8,433.12 km) |
| Holyhead to Endicott (New York) | 3,264.90 mi (5,254.35 km) |
| Holyhead to Endwell (New York) | 3,262.34 mi (5,250.23 km) |
| Holyhead to Englewood (Colorado) | 4,463.62 mi (7,183.51 km) |
| Holyhead to Englewood (Florida) | 4,250.17 mi (6,839.98 km) |
| Holyhead to Englewood (New Jersey) | 3,234.98 mi (5,206.20 km) |
| Holyhead to Englewood (Ohio) | 3,689.79 mi (5,938.15 km) |
| Holyhead to Enid (Oklahoma) | 4,376.08 mi (7,042.61 km) |
| Holyhead to Ennis (Texas) | 4,541.03 mi (7,308.08 km) |
| Holyhead to Ensley (Florida) | 4,266.95 mi (6,866.99 km) |
| Holyhead to Enterprise (Alabama) | 4,168.96 mi (6,709.29 km) |
| Holyhead to Enterprise (Nevada) | 5,006.32 mi (8,056.89 km) |
