| Holyhead to Eau Claire (Wisconsin) | 3,727.92 mi (5,999.51 km) |
| Holyhead to Echelon (New Jersey) | 3,322.69 mi (5,347.35 km) |
| Holyhead to Eden (North Carolina) | 3,668.80 mi (5,904.36 km) |
| Holyhead to Eden Prairie (Minnesota) | 3,797.19 mi (6,110.99 km) |
| Holyhead to Edgewater (Florida) | 4,090.49 mi (6,583.01 km) |
| Holyhead to Edgewater (New Jersey) | 3,238.02 mi (5,211.08 km) |
| Holyhead to Edgewood (Maryland) | 3,394.32 mi (5,462.63 km) |
| Holyhead to Edgewood (Washington) | 4,587.74 mi (7,383.26 km) |
| Holyhead to Edina (Minnesota) | 3,791.63 mi (6,102.04 km) |
| Holyhead to Edinburg (Texas) | 4,918.10 mi (7,914.92 km) |
| Holyhead to Edmond (Oklahoma) | 4,397.13 mi (7,076.50 km) |
| Holyhead to Edmonds (Washington) | 4,556.91 mi (7,333.63 km) |
| Holyhead to Edwards (Colorado) | 4,520.85 mi (7,275.60 km) |
| Holyhead to Edwardsville (Illinois) | 3,959.76 mi (6,372.62 km) |
| Holyhead to Effingham (Illinois) | 3,888.94 mi (6,258.64 km) |
