| Holyhead to Sunbury | 220.20 mi (354.38 km) |
| Holyhead to Sunderland | 171.81 mi (276.49 km) |
| Holyhead to Sunninghill | 213.33 mi (343.32 km) |
| Holyhead to Surbiton | 225.41 mi (362.77 km) |
| Holyhead to Sutton | 230.39 mi (370.78 km) |
| Holyhead to Sutton Coldfield | 127.89 mi (205.82 km) |
| Holyhead to Sutton in Ashfield | 140.07 mi (225.42 km) |
| Holyhead to Sutton on Hull | 180.63 mi (290.70 km) |
| Holyhead to Swadlincote | 133.01 mi (214.06 km) |
| Holyhead to Swallownest | 136.51 mi (219.70 km) |
| Holyhead to Swanage | 218.55 mi (351.72 km) |
| Holyhead to Swindon | 170.40 mi (274.24 km) |
| Holyhead to Swinton | 137.24 mi (220.86 km) |
| Holyhead to Swinton | 95.42 mi (153.57 km) |
| Holyhead to Syston | 153.58 mi (247.16 km) |
