| Holyhead to Stannington | 127.86 mi (205.76 km) |
| Holyhead to Stansted Mountfitchet | 224.88 mi (361.91 km) |
| Holyhead to Stanwell | 217.14 mi (349.46 km) |
| Holyhead to Stapleford | 141.73 mi (228.09 km) |
| Holyhead to Staveley | 135.68 mi (218.35 km) |
| Holyhead to Stepney | 229.56 mi (369.45 km) |
| Holyhead to Stevenage | 209.77 mi (337.59 km) |
| Holyhead to Stevenston | 161.48 mi (259.88 km) |
| Holyhead to Stirling | 195.96 mi (315.37 km) |
| Holyhead to Stockport | 102.64 mi (165.18 km) |
| Holyhead to Stocksbridge | 125.99 mi (202.76 km) |
| Holyhead to Stockton-on-Tees | 160.43 mi (258.19 km) |
| Holyhead to Stoke Gifford | 151.81 mi (244.32 km) |
| Holyhead to Stoke-on-Trent | 103.71 mi (166.91 km) |
| Holyhead to Stone | 106.80 mi (171.87 km) |
