| Holyhead to Southwick | 171.60 mi (276.17 km) |
| Holyhead to Southwick | 252.94 mi (407.06 km) |
| Holyhead to Sowerby Bridge | 115.26 mi (185.49 km) |
| Holyhead to Spalding | 189.53 mi (305.02 km) |
| Holyhead to Spennymoor | 156.52 mi (251.90 km) |
| Holyhead to Spitalfields | 228.49 mi (367.72 km) |
| Holyhead to Spondon | 136.69 mi (219.98 km) |
| Holyhead to Stafford | 110.08 mi (177.15 km) |
| Holyhead to Staines-upon-Thames | 216.78 mi (348.88 km) |
| Holyhead to Stalybridge | 107.50 mi (173.00 km) |
| Holyhead to Stamford | 178.36 mi (287.05 km) |
| Holyhead to Standish | 83.25 mi (133.98 km) |
| Holyhead to Stanford le Hope | 246.52 mi (396.74 km) |
| Holyhead to Stanley | 132.69 mi (213.54 km) |
| Holyhead to Stanmore | 216.06 mi (347.72 km) |
