| Holyhead to Soham | 218.09 mi (350.98 km) |
| Holyhead to Solihull | 134.21 mi (215.99 km) |
| Holyhead to Sompting | 250.09 mi (402.47 km) |
| Holyhead to South Hayling | 233.36 mi (375.55 km) |
| Holyhead to South Normanton | 136.84 mi (220.23 km) |
| Holyhead to South Ockendon | 241.60 mi (388.82 km) |
| Holyhead to South Shields | 174.23 mi (280.40 km) |
| Holyhead to Southall | 218.06 mi (350.94 km) |
| Holyhead to Southampton | 215.41 mi (346.67 km) |
| Holyhead to Southborough | 254.88 mi (410.19 km) |
| Holyhead to Southbourne | 215.56 mi (346.91 km) |
| Holyhead to Southend | 255.72 mi (411.54 km) |
| Holyhead to Southgate | 222.22 mi (357.63 km) |
| Holyhead to Southport | 70.90 mi (114.10 km) |
| Holyhead to Southwater | 240.42 mi (386.92 km) |
