| Holyhead to Shotley Bridge | 155.74 mi (250.63 km) |
| Holyhead to Shrewsbury | 88.46 mi (142.37 km) |
| Holyhead to Sidcup | 238.32 mi (383.54 km) |
| Holyhead to Sidmouth | 191.07 mi (307.50 km) |
| Holyhead to Sileby | 151.91 mi (244.48 km) |
| Holyhead to Sittingbourne | 264.45 mi (425.60 km) |
| Holyhead to Skegness | 206.09 mi (331.67 km) |
| Holyhead to Skelmersdale | 78.24 mi (125.91 km) |
| Holyhead to Skipton | 116.31 mi (187.18 km) |
| Holyhead to Sleaford | 176.16 mi (283.50 km) |
| Holyhead to Slough | 211.00 mi (339.57 km) |
| Holyhead to Small Heath | 129.75 mi (208.82 km) |
| Holyhead to Smethwick | 124.52 mi (200.40 km) |
| Holyhead to Snaresbrook | 228.98 mi (368.50 km) |
| Holyhead to Snodland | 254.39 mi (409.40 km) |
