| Holtsville to Superior (Colorado) | 1,682.03 mi (2,706.96 km) |
| Holtsville to Superior (Wisconsin) | 1,030.01 mi (1,657.65 km) |
| Holtsville to Surprise (Arizona) | 2,203.23 mi (3,545.76 km) |
| Holtsville to Susanville (California) | 2,463.50 mi (3,964.62 km) |
| Holtsville to Sussex (Wisconsin) | 794.81 mi (1,279.12 km) |
| Holtsville to Suwanee (Georgia) | 763.21 mi (1,228.27 km) |
| Holtsville to Swansea (Illinois) | 912.79 mi (1,468.99 km) |
| Holtsville to Sweetwater (Florida) | 1,120.63 mi (1,803.48 km) |
| Holtsville to Sweetwater (Texas) | 1,614.70 mi (2,598.60 km) |
| Holtsville to Sycamore (Illinois) | 813.37 mi (1,308.99 km) |
| Holtsville to Sylacauga (Alabama) | 898.41 mi (1,445.84 km) |
| Holtsville to Sylvania (Ohio) | 556.99 mi (896.39 km) |
| Holtsville to Syosset (New York) | 23.91 mi (38.49 km) |
| Holtsville to Syracuse (New York) | 221.51 mi (356.49 km) |
| Holtsville to Syracuse (Utah) | 2,019.31 mi (3,249.76 km) |
