| Holtsville to Southern Pines (North Carolina) | 519.92 mi (836.73 km) |
| Holtsville to Southfield (Michigan) | 539.49 mi (868.22 km) |
| Holtsville to Southgate (Michigan) | 534.13 mi (859.60 km) |
| Holtsville to Southlake (Texas) | 1,432.65 mi (2,305.63 km) |
| Holtsville to Spanaway (Washington) | 2,452.21 mi (3,946.44 km) |
| Holtsville to Spanish Fork (Utah) | 2,012.95 mi (3,239.53 km) |
| Holtsville to Spanish Lake (Missouri) | 920.20 mi (1,480.92 km) |
| Holtsville to Spanish Springs (Nevada) | 2,431.13 mi (3,912.52 km) |
| Holtsville to Sparks (Nevada) | 2,435.22 mi (3,919.10 km) |
| Holtsville to Spartanburg (South Carolina) | 631.02 mi (1,015.53 km) |
| Holtsville to Spearfish (South Dakota) | 1,574.63 mi (2,534.12 km) |
| Holtsville to Speedway (Indiana) | 698.61 mi (1,124.30 km) |
| Holtsville to Spencer (Iowa) | 1,143.55 mi (1,840.37 km) |
| Holtsville to Spokane (Washington) | 2,215.87 mi (3,566.10 km) |
| Holtsville to Spokane Valley (Washington) | 2,206.69 mi (3,551.32 km) |
