| Holtsville to Scottsboro (Alabama) | 827.35 mi (1,331.49 km) |
| Holtsville to Scottsdale (Arizona) | 2,172.40 mi (3,496.14 km) |
| Holtsville to Scranton (Pennsylvania) | 142.40 mi (229.17 km) |
| Holtsville to Seabrook (Maryland) | 238.12 mi (383.22 km) |
| Holtsville to Seabrook (Texas) | 1,457.48 mi (2,345.59 km) |
| Holtsville to Seaford (New York) | 25.47 mi (40.99 km) |
| Holtsville to Seagoville (Texas) | 1,412.47 mi (2,273.15 km) |
| Holtsville to Seal Beach (California) | 2,494.83 mi (4,015.05 km) |
| Holtsville to Searcy (Arkansas) | 1,084.95 mi (1,746.06 km) |
| Holtsville to Seaside (California) | 2,611.44 mi (4,202.70 km) |
| Holtsville to SeaTac (Washington) | 2,443.07 mi (3,931.74 km) |
| Holtsville to Seattle (Washington) | 2,442.64 mi (3,931.05 km) |
| Holtsville to Sebastian (Florida) | 994.39 mi (1,600.31 km) |
| Holtsville to Sebring (Florida) | 1,038.03 mi (1,670.55 km) |
| Holtsville to Secaucus (New Jersey) | 53.46 mi (86.03 km) |
