| Holtsville to Sanford (Maine) | 215.18 mi (346.30 km) |
| Holtsville to Sanford (North Carolina) | 496.10 mi (798.39 km) |
| Holtsville to Sanger (California) | 2,492.80 mi (4,011.77 km) |
| Holtsville to Santa Ana (California) | 2,485.45 mi (3,999.94 km) |
| Holtsville to Santa Barbara (California) | 2,561.57 mi (4,122.45 km) |
| Holtsville to Santa Clara (California) | 2,600.41 mi (4,184.96 km) |
| Holtsville to Santa Clara (Oregon) | 2,523.70 mi (4,061.51 km) |
| Holtsville to Santa Clarita (California) | 2,498.14 mi (4,020.37 km) |
| Holtsville to Santa Cruz (California) | 2,613.44 mi (4,205.92 km) |
| Holtsville to Santa Fe (New Mexico) | 1,811.45 mi (2,915.24 km) |
| Holtsville to Santa Fe (Texas) | 1,469.07 mi (2,364.24 km) |
| Holtsville to Santa Fe Springs (California) | 2,489.23 mi (4,006.04 km) |
| Holtsville to Santa Maria (California) | 2,585.10 mi (4,160.31 km) |
| Holtsville to Santa Monica (California) | 2,508.48 mi (4,037.00 km) |
| Holtsville to Santa Paula (California) | 2,529.57 mi (4,070.94 km) |
