| Holtsville to Enterprise (Nevada) | 2,285.53 mi (3,678.20 km) |
| Holtsville to Enumclaw (Washington) | 2,431.02 mi (3,912.35 km) |
| Holtsville to Ephrata (Pennsylvania) | 170.46 mi (274.33 km) |
| Holtsville to Erie (Colorado) | 1,674.30 mi (2,694.52 km) |
| Holtsville to Erie (Pennsylvania) | 374.78 mi (603.16 km) |
| Holtsville to Erlanger (Kentucky) | 623.72 mi (1,003.77 km) |
| Holtsville to Escanaba (Michigan) | 783.01 mi (1,260.13 km) |
| Holtsville to Escondido (California) | 2,460.77 mi (3,960.22 km) |
| Holtsville to Española (New Mexico) | 1,807.50 mi (2,908.89 km) |
| Holtsville to Essex (Maryland) | 207.88 mi (334.55 km) |
| Holtsville to Essex Junction (Vermont) | 254.14 mi (408.99 km) |
| Holtsville to Estelle (Louisiana) | 1,220.40 mi (1,964.05 km) |
| Holtsville to Estero (Florida) | 1,112.67 mi (1,790.67 km) |
| Holtsville to Euclid (Ohio) | 443.61 mi (713.93 km) |
| Holtsville to Eufaula (Alabama) | 910.51 mi (1,465.33 km) |
