| Holtsville to Elyria (Ohio) | 473.21 mi (761.57 km) |
| Holtsville to Emeryville (California) | 2,605.54 mi (4,193.21 km) |
| Holtsville to Emmaus (Pennsylvania) | 129.96 mi (209.16 km) |
| Holtsville to Emporia (Kansas) | 1,239.74 mi (1,995.17 km) |
| Holtsville to Encinitas (California) | 2,473.17 mi (3,980.19 km) |
| Holtsville to Endicott (New York) | 179.80 mi (289.36 km) |
| Holtsville to Endwell (New York) | 178.60 mi (287.43 km) |
| Holtsville to Englewood (Colorado) | 1,677.92 mi (2,700.36 km) |
| Holtsville to Englewood (Florida) | 1,093.62 mi (1,760.02 km) |
| Holtsville to Englewood (New Jersey) | 48.85 mi (78.62 km) |
| Holtsville to Englewood (Ohio) | 596.32 mi (959.68 km) |
| Holtsville to Enid (Oklahoma) | 1,369.51 mi (2,204.01 km) |
| Holtsville to Ennis (Texas) | 1,428.45 mi (2,298.87 km) |
| Holtsville to Ensley (Florida) | 1,066.54 mi (1,716.44 km) |
| Holtsville to Enterprise (Alabama) | 967.91 mi (1,557.70 km) |
