| Holt to Enterprise (Nevada) | 1,693.10 mi (2,724.78 km) |
| Holt to Enumclaw (Washington) | 1,841.24 mi (2,963.19 km) |
| Holt to Ephrata (Pennsylvania) | 464.61 mi (747.71 km) |
| Holt to Erie (Colorado) | 1,076.22 mi (1,732.00 km) |
| Holt to Erie (Pennsylvania) | 230.35 mi (370.72 km) |
| Holt to Erlanger (Kentucky) | 250.87 mi (403.74 km) |
| Holt to Escanaba (Michigan) | 249.23 mi (401.09 km) |
| Holt to Escondido (California) | 1,878.12 mi (3,022.54 km) |
| Holt to Española (New Mexico) | 1,234.81 mi (1,987.23 km) |
| Holt to Essex (Maryland) | 480.50 mi (773.29 km) |
| Holt to Essex Junction (Vermont) | 585.13 mi (941.68 km) |
| Holt to Estelle (Louisiana) | 936.53 mi (1,507.20 km) |
| Holt to Estero (Florida) | 1,130.87 mi (1,819.97 km) |
| Holt to Euclid (Ohio) | 170.59 mi (274.55 km) |
| Holt to Eufaula (Alabama) | 742.24 mi (1,194.53 km) |
