| Hilton Head Island to University Place (Washington) | 2,415.68 mi (3,887.67 km) |
| Hilton Head Island to Upland (California) | 2,127.69 mi (3,424.19 km) |
| Hilton Head Island to Upper Arlington (Ohio) | 556.74 mi (895.99 km) |
| Hilton Head Island to Upper Grand Lagoon (Florida) | 326.33 mi (525.18 km) |
| Hilton Head Island to Upper Montclair (New Jersey) | 699.32 mi (1,125.44 km) |
| Hilton Head Island to Urbana (Illinois) | 686.56 mi (1,104.92 km) |
| Hilton Head Island to Urbana (Maryland) | 528.77 mi (850.98 km) |
| Hilton Head Island to Urbana (Ohio) | 572.14 mi (920.76 km) |
| Hilton Head Island to Urbandale (Iowa) | 969.80 mi (1,560.75 km) |
| Hilton Head Island to Utica (New York) | 811.42 mi (1,305.86 km) |
| Hilton Head Island to Uvalde (Texas) | 1,147.37 mi (1,846.52 km) |
| Hilton Head Island to Vacaville (California) | 2,343.94 mi (3,772.20 km) |
| Hilton Head Island to Vadnais Heights (Minnesota) | 1,107.67 mi (1,782.62 km) |
| Hilton Head Island to Vail (Arizona) | 1,746.81 mi (2,811.22 km) |
| Hilton Head Island to Valdosta (Georgia) | 175.35 mi (282.20 km) |
