| Hilton Head Island to Superior (Colorado) | 1,458.70 mi (2,347.55 km) |
| Hilton Head Island to Superior (Wisconsin) | 1,167.71 mi (1,879.25 km) |
| Hilton Head Island to Surprise (Arizona) | 1,834.04 mi (2,951.61 km) |
| Hilton Head Island to Susanville (California) | 2,270.75 mi (3,654.42 km) |
| Hilton Head Island to Sussex (Wisconsin) | 858.74 mi (1,382.00 km) |
| Hilton Head Island to Suwanee (Georgia) | 231.10 mi (371.92 km) |
| Hilton Head Island to Swansea (Illinois) | 680.47 mi (1,095.12 km) |
| Hilton Head Island to Sweetwater (Florida) | 443.54 mi (713.81 km) |
| Hilton Head Island to Sweetwater (Texas) | 1,146.31 mi (1,844.80 km) |
| Hilton Head Island to Sycamore (Illinois) | 805.48 mi (1,296.29 km) |
| Hilton Head Island to Sylacauga (Alabama) | 327.61 mi (527.24 km) |
| Hilton Head Island to Sylvania (Ohio) | 677.66 mi (1,090.59 km) |
| Hilton Head Island to Syosset (New York) | 718.59 mi (1,156.46 km) |
| Hilton Head Island to Syracuse (New York) | 790.65 mi (1,272.42 km) |
| Hilton Head Island to Syracuse (Utah) | 1,830.23 mi (2,945.47 km) |
