| Hilton Head Island to Storm Lake (Iowa) | 1,069.62 mi (1,721.38 km) |
| Hilton Head Island to Storrs (Connecticut) | 812.44 mi (1,307.49 km) |
| Hilton Head Island to Stoughton (Wisconsin) | 873.80 mi (1,406.24 km) |
| Hilton Head Island to Stow (Ohio) | 622.09 mi (1,001.15 km) |
| Hilton Head Island to Streamwood (Illinois) | 792.31 mi (1,275.09 km) |
| Hilton Head Island to Streator (Illinois) | 761.89 mi (1,226.14 km) |
| Hilton Head Island to Streetsboro (Ohio) | 626.16 mi (1,007.71 km) |
| Hilton Head Island to Strongsville (Ohio) | 633.17 mi (1,018.99 km) |
| Hilton Head Island to Stuart (Florida) | 346.36 mi (557.41 km) |
| Hilton Head Island to Stuarts Draft (Virginia) | 414.23 mi (666.64 km) |
| Hilton Head Island to Sturgis (Michigan) | 711.88 mi (1,145.66 km) |
| Hilton Head Island to Suamico (Wisconsin) | 945.82 mi (1,522.15 km) |
| Hilton Head Island to Sudley (Virginia) | 491.17 mi (790.46 km) |
| Hilton Head Island to Suffern (New York) | 716.65 mi (1,153.33 km) |
| Hilton Head Island to Suffolk (Virginia) | 389.47 mi (626.80 km) |
