| Hilton Head Island to Stephenville (Texas) | 1,020.29 mi (1,641.99 km) |
| Hilton Head Island to Sterling (Colorado) | 1,372.00 mi (2,208.02 km) |
| Hilton Head Island to Sterling (Illinois) | 826.35 mi (1,329.88 km) |
| Hilton Head Island to Sterling (Virginia) | 506.92 mi (815.80 km) |
| Hilton Head Island to Sterling Heights (Michigan) | 728.72 mi (1,172.77 km) |
| Hilton Head Island to Steubenville (Ohio) | 564.91 mi (909.14 km) |
| Hilton Head Island to Stevens Point (Wisconsin) | 975.17 mi (1,569.39 km) |
| Hilton Head Island to Stevenson Ranch (California) | 2,178.06 mi (3,505.25 km) |
| Hilton Head Island to Stillwater (Minnesota) | 1,099.96 mi (1,770.22 km) |
| Hilton Head Island to Stillwater (Oklahoma) | 970.85 mi (1,562.43 km) |
| Hilton Head Island to Stockbridge (Georgia) | 222.03 mi (357.32 km) |
| Hilton Head Island to Stockton (California) | 2,309.43 mi (3,716.67 km) |
| Hilton Head Island to Stone Ridge (Virginia) | 498.99 mi (803.05 km) |
| Hilton Head Island to Stonecrest (Georgia) | 221.90 mi (357.11 km) |
| Hilton Head Island to Stony Brook (New York) | 735.32 mi (1,183.38 km) |
