| Hilton Head Island to St. Simons (Georgia) | 79.29 mi (127.61 km) |
| Hilton Head Island to Stafford (Texas) | 895.17 mi (1,440.63 km) |
| Hilton Head Island to Stallings (North Carolina) | 201.76 mi (324.71 km) |
| Hilton Head Island to Stamford (Connecticut) | 733.05 mi (1,179.72 km) |
| Hilton Head Island to Stanford (California) | 2,358.29 mi (3,795.31 km) |
| Hilton Head Island to Stanton (California) | 2,149.39 mi (3,459.11 km) |
| Hilton Head Island to Star (Idaho) | 2,083.66 mi (3,353.32 km) |
| Hilton Head Island to Starkville (Mississippi) | 477.14 mi (767.88 km) |
| Hilton Head Island to State College (Pennsylvania) | 615.53 mi (990.61 km) |
| Hilton Head Island to Staten Island (New York) | 685.89 mi (1,103.83 km) |
| Hilton Head Island to Statesboro (Georgia) | 62.27 mi (100.21 km) |
| Hilton Head Island to Statesville (North Carolina) | 248.46 mi (399.86 km) |
| Hilton Head Island to Staunton (Virginia) | 423.33 mi (681.28 km) |
| Hilton Head Island to Steamboat Springs (Colorado) | 1,552.95 mi (2,499.23 km) |
| Hilton Head Island to Steiner Ranch (Texas) | 1,019.21 mi (1,640.26 km) |
