| Hilton Head Island to St. George (Utah) | 1,886.79 mi (3,036.49 km) |
| Hilton Head Island to St. Helens (Oregon) | 2,413.55 mi (3,884.23 km) |
| Hilton Head Island to St. James (New York) | 732.90 mi (1,179.49 km) |
| Hilton Head Island to St. John (Indiana) | 738.95 mi (1,189.23 km) |
| Hilton Head Island to St. Joseph (Missouri) | 942.99 mi (1,517.59 km) |
| Hilton Head Island to St. Louis (Missouri) | 695.19 mi (1,118.80 km) |
| Hilton Head Island to St. Louis Park (Minnesota) | 1,111.42 mi (1,788.66 km) |
| Hilton Head Island to St. Marys (Georgia) | 110.23 mi (177.39 km) |
| Hilton Head Island to St. Marys (Pennsylvania) | 651.90 mi (1,049.12 km) |
| Hilton Head Island to St. Matthews (Kentucky) | 501.27 mi (806.71 km) |
| Hilton Head Island to St. Michael (Minnesota) | 1,135.07 mi (1,826.72 km) |
| Hilton Head Island to St. Paul (Minnesota) | 1,102.91 mi (1,774.96 km) |
| Hilton Head Island to St. Peter (Minnesota) | 1,100.57 mi (1,771.19 km) |
| Hilton Head Island to St. Peters (Missouri) | 716.85 mi (1,153.65 km) |
| Hilton Head Island to St. Petersburg (Florida) | 324.65 mi (522.48 km) |
