| Hilton Head Island to Southern Pines (North Carolina) | 221.45 mi (356.38 km) |
| Hilton Head Island to Southfield (Michigan) | 723.92 mi (1,165.03 km) |
| Hilton Head Island to Southgate (Michigan) | 704.96 mi (1,134.53 km) |
| Hilton Head Island to Southlake (Texas) | 955.43 mi (1,537.61 km) |
| Hilton Head Island to Spanaway (Washington) | 2,408.58 mi (3,876.24 km) |
| Hilton Head Island to Spanish Fork (Utah) | 1,797.75 mi (2,893.20 km) |
| Hilton Head Island to Spanish Lake (Missouri) | 699.98 mi (1,126.51 km) |
| Hilton Head Island to Spanish Springs (Nevada) | 2,219.58 mi (3,572.06 km) |
| Hilton Head Island to Sparks (Nevada) | 2,221.96 mi (3,575.90 km) |
| Hilton Head Island to Spartanburg (South Carolina) | 201.99 mi (325.07 km) |
| Hilton Head Island to Spearfish (South Dakota) | 1,503.11 mi (2,419.03 km) |
| Hilton Head Island to Speedway (Indiana) | 608.38 mi (979.10 km) |
| Hilton Head Island to Spencer (Iowa) | 1,089.59 mi (1,753.52 km) |
| Hilton Head Island to Spokane (Washington) | 2,189.87 mi (3,524.25 km) |
| Hilton Head Island to Spokane Valley (Washington) | 2,180.90 mi (3,509.82 km) |
