| Hilton Head Island to Smyrna (Delaware) | 569.00 mi (915.72 km) |
| Hilton Head Island to Smyrna (Georgia) | 246.94 mi (397.40 km) |
| Hilton Head Island to Smyrna (Tennessee) | 421.11 mi (677.71 km) |
| Hilton Head Island to Snellville (Georgia) | 220.87 mi (355.46 km) |
| Hilton Head Island to Snoqualmie (Washington) | 2,387.32 mi (3,842.01 km) |
| Hilton Head Island to Snyder (Texas) | 1,174.30 mi (1,889.85 km) |
| Hilton Head Island to Socastee (South Carolina) | 144.57 mi (232.66 km) |
| Hilton Head Island to Socorro (Texas) | 1,493.13 mi (2,402.96 km) |
| Hilton Head Island to Soddy-Daisy (Tennessee) | 330.92 mi (532.57 km) |
| Hilton Head Island to Solana Beach (California) | 2,115.18 mi (3,404.06 km) |
| Hilton Head Island to Soledad (California) | 2,318.00 mi (3,730.46 km) |
| Hilton Head Island to Solon (Ohio) | 636.58 mi (1,024.48 km) |
| Hilton Head Island to Somers Point (New Jersey) | 600.60 mi (966.57 km) |
| Hilton Head Island to Somerset (Kentucky) | 403.03 mi (648.61 km) |
| Hilton Head Island to Somerset (New Jersey) | 671.33 mi (1,080.40 km) |
