| Hilton Head Island to Silver Firs (Washington) | 2,405.93 mi (3,871.97 km) |
| Hilton Head Island to Silver Spring (Maryland) | 515.13 mi (829.03 km) |
| Hilton Head Island to Silver Springs Shores (Florida) | 225.50 mi (362.91 km) |
| Hilton Head Island to Silverdale (Washington) | 2,427.61 mi (3,906.87 km) |
| Hilton Head Island to Silverton (Oregon) | 2,404.21 mi (3,869.21 km) |
| Hilton Head Island to Simi Valley (California) | 2,188.19 mi (3,521.56 km) |
| Hilton Head Island to Simpsonville (South Carolina) | 195.76 mi (315.04 km) |
| Hilton Head Island to Sioux City (Iowa) | 1,112.66 mi (1,790.65 km) |
| Hilton Head Island to Sioux Falls (South Dakota) | 1,168.76 mi (1,880.94 km) |
| Hilton Head Island to Skokie (Illinois) | 781.10 mi (1,257.05 km) |
| Hilton Head Island to Sleepy Hollow (New York) | 723.20 mi (1,163.88 km) |
| Hilton Head Island to Slidell (Louisiana) | 549.35 mi (884.10 km) |
| Hilton Head Island to Smithfield (North Carolina) | 267.76 mi (430.92 km) |
| Hilton Head Island to Smithfield (Utah) | 1,827.13 mi (2,940.49 km) |
| Hilton Head Island to Smithville (Missouri) | 919.21 mi (1,479.33 km) |
