| Hilton Head Island to Shelton (Connecticut) | 757.12 mi (1,218.47 km) |
| Hilton Head Island to Shelton (Washington) | 2,441.90 mi (3,929.85 km) |
| Hilton Head Island to Shenandoah (Louisiana) | 617.49 mi (993.76 km) |
| Hilton Head Island to Shepherdsville (Kentucky) | 488.16 mi (785.62 km) |
| Hilton Head Island to Sheridan (Wyoming) | 1,652.59 mi (2,659.59 km) |
| Hilton Head Island to Sherman (Texas) | 925.11 mi (1,488.82 km) |
| Hilton Head Island to Sherrelwood (Colorado) | 1,449.03 mi (2,331.98 km) |
| Hilton Head Island to Sherwood (Arkansas) | 684.41 mi (1,101.45 km) |
| Hilton Head Island to Sherwood (Oregon) | 2,410.23 mi (3,878.89 km) |
| Hilton Head Island to Shiloh (Illinois) | 677.60 mi (1,090.49 km) |
| Hilton Head Island to Shiloh (Ohio) | 561.59 mi (903.79 km) |
| Hilton Head Island to Shiloh (Pennsylvania) | 581.26 mi (935.45 km) |
| Hilton Head Island to Shirley (New York) | 737.36 mi (1,186.67 km) |
| Hilton Head Island to Shively (Kentucky) | 503.81 mi (810.81 km) |
| Hilton Head Island to Shoreline (Washington) | 2,413.26 mi (3,883.77 km) |
