| Hilton Head Island to Seymour (Tennessee) | 307.85 mi (495.44 km) |
| Hilton Head Island to Shady Hills (Florida) | 282.65 mi (454.87 km) |
| Hilton Head Island to Shafter (California) | 2,204.62 mi (3,547.99 km) |
| Hilton Head Island to Shaker Heights (Ohio) | 643.03 mi (1,034.86 km) |
| Hilton Head Island to Shakopee (Minnesota) | 1,106.19 mi (1,780.24 km) |
| Hilton Head Island to Sharon (Pennsylvania) | 625.06 mi (1,005.94 km) |
| Hilton Head Island to Sharonville (Ohio) | 531.13 mi (854.77 km) |
| Hilton Head Island to Shasta Lake (California) | 2,363.74 mi (3,804.08 km) |
| Hilton Head Island to Shawnee (Kansas) | 918.25 mi (1,477.78 km) |
| Hilton Head Island to Shawnee (Oklahoma) | 955.39 mi (1,537.55 km) |
| Hilton Head Island to Sheboygan (Wisconsin) | 883.24 mi (1,421.43 km) |
| Hilton Head Island to Shelby (North Carolina) | 219.06 mi (352.54 km) |
| Hilton Head Island to Shelbyville (Indiana) | 580.17 mi (933.70 km) |
| Hilton Head Island to Shelbyville (Kentucky) | 486.46 mi (782.88 km) |
| Hilton Head Island to Shelbyville (Tennessee) | 399.05 mi (642.20 km) |
