| Hilton Head Island to Security-Widefield (Colorado) | 1,417.68 mi (2,281.54 km) |
| Hilton Head Island to Sedalia (Missouri) | 833.35 mi (1,341.15 km) |
| Hilton Head Island to Sedro-Woolley (Washington) | 2,418.84 mi (3,892.75 km) |
| Hilton Head Island to Seguin (Texas) | 1,035.40 mi (1,666.31 km) |
| Hilton Head Island to Selden (New York) | 736.01 mi (1,184.49 km) |
| Hilton Head Island to Selma (Alabama) | 367.25 mi (591.03 km) |
| Hilton Head Island to Selma (California) | 2,221.62 mi (3,575.36 km) |
| Hilton Head Island to Selma (Texas) | 1,055.56 mi (1,698.76 km) |
| Hilton Head Island to Seminole (Florida) | 323.99 mi (521.40 km) |
| Hilton Head Island to Seven Hills (Ohio) | 637.06 mi (1,025.25 km) |
| Hilton Head Island to Seven Oaks (South Carolina) | 130.37 mi (209.82 km) |
| Hilton Head Island to Severn (Maryland) | 530.99 mi (854.54 km) |
| Hilton Head Island to Severna Park (Maryland) | 531.09 mi (854.71 km) |
| Hilton Head Island to Sevierville (Tennessee) | 302.12 mi (486.22 km) |
| Hilton Head Island to Seymour (Indiana) | 548.86 mi (883.31 km) |
