| Hilton Head Island to Scottsboro (Alabama) | 349.43 mi (562.35 km) |
| Hilton Head Island to Scottsdale (Arizona) | 1,800.45 mi (2,897.54 km) |
| Hilton Head Island to Scranton (Pennsylvania) | 695.73 mi (1,119.67 km) |
| Hilton Head Island to Seabrook (Maryland) | 517.69 mi (833.14 km) |
| Hilton Head Island to Seabrook (Texas) | 864.74 mi (1,391.66 km) |
| Hilton Head Island to Seaford (New York) | 710.69 mi (1,143.74 km) |
| Hilton Head Island to Seagoville (Texas) | 920.97 mi (1,482.16 km) |
| Hilton Head Island to Seal Beach (California) | 2,154.24 mi (3,466.92 km) |
| Hilton Head Island to Searcy (Arkansas) | 665.18 mi (1,070.51 km) |
| Hilton Head Island to Seaside (California) | 2,343.36 mi (3,771.27 km) |
| Hilton Head Island to SeaTac (Washington) | 2,407.16 mi (3,873.95 km) |
| Hilton Head Island to Seattle (Washington) | 2,410.64 mi (3,879.55 km) |
| Hilton Head Island to Sebastian (Florida) | 304.94 mi (490.76 km) |
| Hilton Head Island to Sebring (Florida) | 328.32 mi (528.38 km) |
| Hilton Head Island to Secaucus (New Jersey) | 699.64 mi (1,125.97 km) |
