| Hilton Head Island to Savannah (Georgia) | 27.63 mi (44.47 km) |
| Hilton Head Island to Sayreville (New Jersey) | 674.02 mi (1,084.73 km) |
| Hilton Head Island to Sayville (New York) | 728.08 mi (1,171.72 km) |
| Hilton Head Island to Scaggsville (Maryland) | 526.93 mi (848.01 km) |
| Hilton Head Island to Scarsdale (New York) | 720.08 mi (1,158.86 km) |
| Hilton Head Island to Schaumburg (Illinois) | 790.23 mi (1,271.76 km) |
| Hilton Head Island to Schenectady (New York) | 822.44 mi (1,323.58 km) |
| Hilton Head Island to Schererville (Indiana) | 740.78 mi (1,192.17 km) |
| Hilton Head Island to Schertz (Texas) | 1,052.46 mi (1,693.76 km) |
| Hilton Head Island to Schiller Park (Illinois) | 780.09 mi (1,255.43 km) |
| Hilton Head Island to Schofield Barracks (Hawaii) | 4,725.89 mi (7,605.59 km) |
| Hilton Head Island to Scotchtown (New York) | 731.82 mi (1,177.75 km) |
| Hilton Head Island to Scottdale (Georgia) | 231.84 mi (373.12 km) |
| Hilton Head Island to Scotts Valley (California) | 2,351.56 mi (3,784.47 km) |
| Hilton Head Island to Scottsbluff (Nebraska) | 1,423.48 mi (2,290.87 km) |
