| Hilton Head Island to Santa Rosa (California) | 2,383.68 mi (3,836.16 km) |
| Hilton Head Island to Santaquin (Utah) | 1,804.51 mi (2,904.08 km) |
| Hilton Head Island to Santee (California) | 2,101.02 mi (3,381.27 km) |
| Hilton Head Island to Sapulpa (Oklahoma) | 915.88 mi (1,473.97 km) |
| Hilton Head Island to Saraland (Alabama) | 442.66 mi (712.39 km) |
| Hilton Head Island to Sarasota (Florida) | 351.98 mi (566.46 km) |
| Hilton Head Island to Sarasota Springs (Florida) | 352.73 mi (567.67 km) |
| Hilton Head Island to Saratoga (California) | 2,351.30 mi (3,784.05 km) |
| Hilton Head Island to Saratoga Springs (New York) | 842.12 mi (1,355.26 km) |
| Hilton Head Island to Saratoga Springs (Utah) | 1,814.38 mi (2,919.96 km) |
| Hilton Head Island to Sartell (Minnesota) | 1,173.66 mi (1,888.82 km) |
| Hilton Head Island to Satellite Beach (Florida) | 277.30 mi (446.27 km) |
| Hilton Head Island to Sauk Rapids (Minnesota) | 1,170.42 mi (1,883.61 km) |
| Hilton Head Island to Sault Ste. Marie (Michigan) | 1,005.99 mi (1,618.98 km) |
| Hilton Head Island to Savage (Minnesota) | 1,101.40 mi (1,772.53 km) |
