| Hilton Head Island to Sanford (Maine) | 947.18 mi (1,524.34 km) |
| Hilton Head Island to Sanford (North Carolina) | 245.08 mi (394.42 km) |
| Hilton Head Island to Sanger (California) | 2,217.91 mi (3,569.39 km) |
| Hilton Head Island to Santa Ana (California) | 2,143.61 mi (3,449.81 km) |
| Hilton Head Island to Santa Barbara (California) | 2,241.77 mi (3,607.78 km) |
| Hilton Head Island to Santa Clara (California) | 2,347.65 mi (3,778.18 km) |
| Hilton Head Island to Santa Clara (Oregon) | 2,415.06 mi (3,886.66 km) |
| Hilton Head Island to Santa Clarita (California) | 2,172.63 mi (3,496.51 km) |
| Hilton Head Island to Santa Cruz (California) | 2,353.22 mi (3,787.13 km) |
| Hilton Head Island to Santa Fe (New Mexico) | 1,462.18 mi (2,353.15 km) |
| Hilton Head Island to Santa Fe (Texas) | 872.73 mi (1,404.52 km) |
| Hilton Head Island to Santa Fe Springs (California) | 2,152.12 mi (3,463.51 km) |
| Hilton Head Island to Santa Maria (California) | 2,278.30 mi (3,666.58 km) |
| Hilton Head Island to Santa Monica (California) | 2,175.10 mi (3,500.49 km) |
| Hilton Head Island to Santa Paula (California) | 2,205.37 mi (3,549.21 km) |
