| Hilton Head Island to San Luis Obispo (California) | 2,288.37 mi (3,682.78 km) |
| Hilton Head Island to San Marcos (California) | 2,108.99 mi (3,394.09 km) |
| Hilton Head Island to San Marcos (Texas) | 1,028.84 mi (1,655.75 km) |
| Hilton Head Island to San Marino (California) | 2,153.36 mi (3,465.50 km) |
| Hilton Head Island to San Mateo (California) | 2,365.63 mi (3,807.12 km) |
| Hilton Head Island to San Pablo (California) | 2,365.60 mi (3,807.07 km) |
| Hilton Head Island to San Rafael (California) | 2,375.26 mi (3,822.61 km) |
| Hilton Head Island to San Ramon (California) | 2,344.25 mi (3,772.71 km) |
| Hilton Head Island to San Tan Valley (Arizona) | 1,786.71 mi (2,875.43 km) |
| Hilton Head Island to Sand Springs (Oklahoma) | 919.30 mi (1,479.48 km) |
| Hilton Head Island to Sandusky (Ohio) | 648.61 mi (1,043.84 km) |
| Hilton Head Island to Sandy (Oregon) | 2,383.02 mi (3,835.10 km) |
| Hilton Head Island to Sandy (Utah) | 1,813.29 mi (2,918.21 km) |
| Hilton Head Island to Sandy Springs (Georgia) | 241.88 mi (389.27 km) |
| Hilton Head Island to Sanford (Florida) | 237.03 mi (381.46 km) |
