| Hilton Head Island to San Diego (California) | 2,109.14 mi (3,394.34 km) |
| Hilton Head Island to San Diego Country Estates (California) | 2,088.09 mi (3,360.46 km) |
| Hilton Head Island to San Dimas (California) | 2,136.21 mi (3,437.90 km) |
| Hilton Head Island to San Fernando (California) | 2,170.28 mi (3,492.73 km) |
| Hilton Head Island to San Francisco (California) | 2,372.00 mi (3,817.37 km) |
| Hilton Head Island to San Gabriel (California) | 2,152.79 mi (3,464.58 km) |
| Hilton Head Island to San Germán (Puerto Rico) | 1,295.36 mi (2,084.69 km) |
| Hilton Head Island to San Jacinto (California) | 2,092.37 mi (3,367.34 km) |
| Hilton Head Island to San Jose (California) | 2,341.36 mi (3,768.06 km) |
| Hilton Head Island to San Juan (Puerto Rico) | 1,319.96 mi (2,124.27 km) |
| Hilton Head Island to San Juan (Texas) | 1,126.79 mi (1,813.40 km) |
| Hilton Head Island to San Juan Capistrano (California) | 2,132.85 mi (3,432.49 km) |
| Hilton Head Island to San Leandro (California) | 2,356.66 mi (3,792.67 km) |
| Hilton Head Island to San Lorenzo (California) | 2,355.34 mi (3,790.55 km) |
| Hilton Head Island to San Luis (Arizona) | 1,973.99 mi (3,176.83 km) |
