| Hilton Head Island to Salisbury (New York) | 712.87 mi (1,147.25 km) |
| Hilton Head Island to Salisbury (North Carolina) | 240.64 mi (387.28 km) |
| Hilton Head Island to Salmon Creek (Washington) | 2,404.83 mi (3,870.19 km) |
| Hilton Head Island to Salt Lake City (Utah) | 1,819.66 mi (2,928.45 km) |
| Hilton Head Island to Sammamish (Washington) | 2,397.45 mi (3,858.33 km) |
| Hilton Head Island to San Angelo (Texas) | 1,156.19 mi (1,860.71 km) |
| Hilton Head Island to San Anselmo (California) | 2,377.89 mi (3,826.85 km) |
| Hilton Head Island to San Antonio (Texas) | 1,069.95 mi (1,721.92 km) |
| Hilton Head Island to San Benito (Texas) | 1,100.31 mi (1,770.77 km) |
| Hilton Head Island to San Bernardino (California) | 2,106.71 mi (3,390.41 km) |
| Hilton Head Island to San Bruno (California) | 2,371.82 mi (3,817.07 km) |
| Hilton Head Island to San Buenaventura (California) | 2,215.46 mi (3,565.43 km) |
| Hilton Head Island to San Carlos (California) | 2,363.45 mi (3,803.60 km) |
| Hilton Head Island to San Carlos Park (Florida) | 399.95 mi (643.66 km) |
| Hilton Head Island to San Clemente (California) | 2,130.81 mi (3,429.21 km) |
