| Hilton Head Island to Saddlebrooke (Arizona) | 1,752.14 mi (2,819.79 km) |
| Hilton Head Island to Safety Harbor (Florida) | 311.45 mi (501.23 km) |
| Hilton Head Island to Saginaw (Michigan) | 795.19 mi (1,279.73 km) |
| Hilton Head Island to Saginaw (Texas) | 968.06 mi (1,557.94 km) |
| Hilton Head Island to Sahuarita (Arizona) | 1,763.48 mi (2,838.05 km) |
| Hilton Head Island to Saks (Alabama) | 314.00 mi (505.33 km) |
| Hilton Head Island to Salem (Massachusetts) | 893.79 mi (1,438.42 km) |
| Hilton Head Island to Salem (Ohio) | 602.19 mi (969.14 km) |
| Hilton Head Island to Salem (Oregon) | 2,415.40 mi (3,887.21 km) |
| Hilton Head Island to Salem (Virginia) | 354.35 mi (570.27 km) |
| Hilton Head Island to Salem Lakes (Wisconsin) | 821.01 mi (1,321.29 km) |
| Hilton Head Island to Salida (California) | 2,297.94 mi (3,698.17 km) |
| Hilton Head Island to Salina (Kansas) | 1,050.99 mi (1,691.40 km) |
| Hilton Head Island to Salinas (California) | 2,332.59 mi (3,753.93 km) |
| Hilton Head Island to Salisbury (Maryland) | 516.98 mi (832.00 km) |
