| Hilton Head Island to Oswego (Illinois) | 777.61 mi (1,251.45 km) |
| Hilton Head Island to Oswego (New York) | 811.65 mi (1,306.23 km) |
| Hilton Head Island to Otsego (Minnesota) | 1,136.05 mi (1,828.30 km) |
| Hilton Head Island to Ottawa (Illinois) | 774.34 mi (1,246.18 km) |
| Hilton Head Island to Ottawa (Kansas) | 928.14 mi (1,493.69 km) |
| Hilton Head Island to Ottumwa (Iowa) | 887.90 mi (1,428.94 km) |
| Hilton Head Island to Overland (Missouri) | 703.05 mi (1,131.44 km) |
| Hilton Head Island to Overland Park (Kansas) | 908.48 mi (1,462.06 km) |
| Hilton Head Island to Overlea (Maryland) | 549.39 mi (884.15 km) |
| Hilton Head Island to Oviedo (Florida) | 245.40 mi (394.93 km) |
| Hilton Head Island to Owasso (Oklahoma) | 905.61 mi (1,457.43 km) |
| Hilton Head Island to Owatonna (Minnesota) | 1,063.40 mi (1,711.38 km) |
| Hilton Head Island to Owensboro (Kentucky) | 526.93 mi (848.01 km) |
| Hilton Head Island to Owings Mills (Maryland) | 545.91 mi (878.56 km) |
| Hilton Head Island to Owosso (Michigan) | 769.63 mi (1,238.59 km) |
