| Hilton Head Island to Orangevale (California) | 2,302.87 mi (3,706.11 km) |
| Hilton Head Island to Orchards (Washington) | 2,398.29 mi (3,859.67 km) |
| Hilton Head Island to Orcutt (California) | 2,277.65 mi (3,665.53 km) |
| Hilton Head Island to Oregon (Ohio) | 670.29 mi (1,078.73 km) |
| Hilton Head Island to Oregon (Wisconsin) | 878.72 mi (1,414.17 km) |
| Hilton Head Island to Oregon City (Oregon) | 2,398.02 mi (3,859.24 km) |
| Hilton Head Island to Orem (Utah) | 1,802.65 mi (2,901.09 km) |
| Hilton Head Island to Orinda (California) | 2,357.01 mi (3,793.24 km) |
| Hilton Head Island to Orland Park (Illinois) | 759.50 mi (1,222.30 km) |
| Hilton Head Island to Orlando (Florida) | 258.87 mi (416.61 km) |
| Hilton Head Island to Ormond Beach (Florida) | 200.84 mi (323.23 km) |
| Hilton Head Island to Oro Valley (Arizona) | 1,759.31 mi (2,831.34 km) |
| Hilton Head Island to Oroville (California) | 2,320.37 mi (3,734.27 km) |
| Hilton Head Island to Oshkosh (Wisconsin) | 920.27 mi (1,481.03 km) |
| Hilton Head Island to Oskaloosa (Iowa) | 908.83 mi (1,462.63 km) |
