| Hilton Head Island to Olympia Heights (Florida) | 447.42 mi (720.05 km) |
| Hilton Head Island to Omaha (Nebraska) | 1,051.49 mi (1,692.21 km) |
| Hilton Head Island to On Top of the World Designated Place (Florida) | 231.82 mi (373.07 km) |
| Hilton Head Island to Onalaska (Wisconsin) | 986.74 mi (1,588.00 km) |
| Hilton Head Island to Oneida (New York) | 801.68 mi (1,290.18 km) |
| Hilton Head Island to Oneonta (New York) | 774.49 mi (1,246.43 km) |
| Hilton Head Island to Ontario (California) | 2,125.28 mi (3,420.31 km) |
| Hilton Head Island to Ontario (Oregon) | 2,111.40 mi (3,397.98 km) |
| Hilton Head Island to Opa-locka (Florida) | 435.61 mi (701.05 km) |
| Hilton Head Island to Opelika (Alabama) | 271.79 mi (437.40 km) |
| Hilton Head Island to Opelousas (Louisiana) | 678.06 mi (1,091.24 km) |
| Hilton Head Island to Orange (California) | 2,139.58 mi (3,443.33 km) |
| Hilton Head Island to Orange (Texas) | 781.92 mi (1,258.37 km) |
| Hilton Head Island to Orange City (Florida) | 227.15 mi (365.57 km) |
| Hilton Head Island to Orangeburg (South Carolina) | 90.30 mi (145.32 km) |
