| Hilton Head Island to Odessa (Texas) | 1,262.91 mi (2,032.46 km) |
| Hilton Head Island to Ogden (Utah) | 1,826.67 mi (2,939.74 km) |
| Hilton Head Island to Oildale (California) | 2,195.38 mi (3,533.12 km) |
| Hilton Head Island to Ojus (Florida) | 432.14 mi (695.47 km) |
| Hilton Head Island to Okemos (Michigan) | 753.66 mi (1,212.90 km) |
| Hilton Head Island to Oklahoma City (Oklahoma) | 987.13 mi (1,588.63 km) |
| Hilton Head Island to Okmulgee (Oklahoma) | 905.28 mi (1,456.91 km) |
| Hilton Head Island to Olathe (Kansas) | 914.79 mi (1,472.21 km) |
| Hilton Head Island to Old Jamestown (Missouri) | 705.41 mi (1,135.25 km) |
| Hilton Head Island to Oldsmar (Florida) | 308.12 mi (495.87 km) |
| Hilton Head Island to Olean (New York) | 695.23 mi (1,118.87 km) |
| Hilton Head Island to Olive Branch (Mississippi) | 557.32 mi (896.91 km) |
| Hilton Head Island to Olivehurst (California) | 2,320.36 mi (3,734.25 km) |
| Hilton Head Island to Olney (Maryland) | 523.01 mi (841.71 km) |
| Hilton Head Island to Olympia (Washington) | 2,429.83 mi (3,910.43 km) |
