| Hilton Head Island to Medford (New York) | 735.28 mi (1,183.32 km) |
| Hilton Head Island to Medford (Oregon) | 2,392.18 mi (3,849.83 km) |
| Hilton Head Island to Medina (Ohio) | 621.21 mi (999.75 km) |
| Hilton Head Island to Medulla (Florida) | 301.64 mi (485.44 km) |
| Hilton Head Island to Mehlville (Missouri) | 692.70 mi (1,114.79 km) |
| Hilton Head Island to Melbourne (Florida) | 282.02 mi (453.86 km) |
| Hilton Head Island to Melissa (Texas) | 920.93 mi (1,482.10 km) |
| Hilton Head Island to Melrose (Massachusetts) | 885.61 mi (1,425.26 km) |
| Hilton Head Island to Melrose Park (Illinois) | 776.69 mi (1,249.96 km) |
| Hilton Head Island to Melville (New York) | 719.64 mi (1,158.15 km) |
| Hilton Head Island to Melvindale (Michigan) | 709.78 mi (1,142.29 km) |
| Hilton Head Island to Memphis (Florida) | 338.84 mi (545.30 km) |
| Hilton Head Island to Memphis (Tennessee) | 566.88 mi (912.30 km) |
| Hilton Head Island to Menasha (Wisconsin) | 928.39 mi (1,494.09 km) |
| Hilton Head Island to Mendota (California) | 2,262.98 mi (3,641.91 km) |
