| Hilton Head Island to Iselin (New Jersey) | 680.18 mi (1,094.65 km) |
| Hilton Head Island to Isla Vista (California) | 2,249.89 mi (3,620.85 km) |
| Hilton Head Island to Issaquah (Washington) | 2,396.93 mi (3,857.49 km) |
| Hilton Head Island to Ithaca (New York) | 745.69 mi (1,200.07 km) |
| Hilton Head Island to Ives Estates (Florida) | 431.56 mi (694.53 km) |
| Hilton Head Island to Jackson (Michigan) | 722.94 mi (1,163.46 km) |
| Hilton Head Island to Jackson (Mississippi) | 552.81 mi (889.66 km) |
| Hilton Head Island to Jackson (Missouri) | 619.01 mi (996.21 km) |
| Hilton Head Island to Jackson (Tennessee) | 521.46 mi (839.21 km) |
| Hilton Head Island to Jackson (Wyoming) | 1,801.24 mi (2,898.82 km) |
| Hilton Head Island to Jacksonville (Alabama) | 310.79 mi (500.16 km) |
| Hilton Head Island to Jacksonville (Arkansas) | 680.84 mi (1,095.71 km) |
| Hilton Head Island to Jacksonville (Florida) | 139.48 mi (224.47 km) |
| Hilton Head Island to Jacksonville (Illinois) | 742.50 mi (1,194.94 km) |
| Hilton Head Island to Jacksonville (North Carolina) | 261.12 mi (420.23 km) |
