| Hilton Head Island to Indianola (Iowa) | 949.26 mi (1,527.68 km) |
| Hilton Head Island to Indio (California) | 2,049.75 mi (3,298.75 km) |
| Hilton Head Island to Inglewood (California) | 2,167.94 mi (3,488.96 km) |
| Hilton Head Island to Inkster (Michigan) | 712.12 mi (1,146.05 km) |
| Hilton Head Island to Inver Grove Heights (Minnesota) | 1,095.09 mi (1,762.37 km) |
| Hilton Head Island to Inwood (New York) | 700.11 mi (1,126.71 km) |
| Hilton Head Island to Iona (Florida) | 398.71 mi (641.67 km) |
| Hilton Head Island to Ionia (Michigan) | 781.74 mi (1,258.08 km) |
| Hilton Head Island to Iowa City (Iowa) | 883.07 mi (1,421.17 km) |
| Hilton Head Island to Irmo (South Carolina) | 134.61 mi (216.64 km) |
| Hilton Head Island to Irondale (Alabama) | 355.49 mi (572.11 km) |
| Hilton Head Island to Ironton (Ohio) | 451.47 mi (726.57 km) |
| Hilton Head Island to Irvine (California) | 2,138.00 mi (3,440.78 km) |
| Hilton Head Island to Irving (Texas) | 945.15 mi (1,521.07 km) |
| Hilton Head Island to Isabela (Puerto Rico) | 1,274.00 mi (2,050.30 km) |
