| Hilton Head Island to Enterprise (Nevada) | 1,979.83 mi (3,186.22 km) |
| Hilton Head Island to Enumclaw (Washington) | 2,389.84 mi (3,846.07 km) |
| Hilton Head Island to Ephrata (Pennsylvania) | 607.87 mi (978.27 km) |
| Hilton Head Island to Erie (Colorado) | 1,454.38 mi (2,340.59 km) |
| Hilton Head Island to Erie (Pennsylvania) | 686.90 mi (1,105.46 km) |
| Hilton Head Island to Erlanger (Kentucky) | 518.11 mi (833.82 km) |
| Hilton Head Island to Escanaba (Michigan) | 995.94 mi (1,602.80 km) |
| Hilton Head Island to Escondido (California) | 2,103.15 mi (3,384.69 km) |
| Hilton Head Island to Española (New Mexico) | 1,468.09 mi (2,362.66 km) |
| Hilton Head Island to Essex (Maryland) | 547.34 mi (880.86 km) |
| Hilton Head Island to Essex Junction (Vermont) | 944.22 mi (1,519.58 km) |
| Hilton Head Island to Estelle (Louisiana) | 576.76 mi (928.20 km) |
| Hilton Head Island to Estero (Florida) | 403.06 mi (648.66 km) |
| Hilton Head Island to Euclid (Ohio) | 650.91 mi (1,047.53 km) |
| Hilton Head Island to Eufaula (Alabama) | 258.41 mi (415.88 km) |
