| Hilton Head Island to Elyria (Ohio) | 639.11 mi (1,028.55 km) |
| Hilton Head Island to Emeryville (California) | 2,363.40 mi (3,803.52 km) |
| Hilton Head Island to Emmaus (Pennsylvania) | 646.12 mi (1,039.83 km) |
| Hilton Head Island to Emporia (Kansas) | 969.19 mi (1,559.76 km) |
| Hilton Head Island to Encinitas (California) | 2,114.82 mi (3,403.48 km) |
| Hilton Head Island to Endicott (New York) | 731.32 mi (1,176.94 km) |
| Hilton Head Island to Endwell (New York) | 733.44 mi (1,180.35 km) |
| Hilton Head Island to Englewood (Colorado) | 1,445.55 mi (2,326.38 km) |
| Hilton Head Island to Englewood (Florida) | 373.14 mi (600.51 km) |
| Hilton Head Island to Englewood (New Jersey) | 708.68 mi (1,140.51 km) |
| Hilton Head Island to Englewood (Ohio) | 566.16 mi (911.15 km) |
| Hilton Head Island to Enid (Oklahoma) | 1,018.09 mi (1,638.46 km) |
| Hilton Head Island to Ennis (Texas) | 927.33 mi (1,492.40 km) |
| Hilton Head Island to Ensley (Florida) | 401.61 mi (646.32 km) |
| Hilton Head Island to Enterprise (Alabama) | 305.24 mi (491.24 km) |
